![]() ![]() Midazolam mechanism of action is due to activation of alpha-1 subunits of GABA-A receptors whereas anxiolytic effect is due to alpha-2 subunit activity. This resistance to excitation is presumed to be the mechanism by which benzodiazepines produce anxiolysis, sedation, anterograde amnesia, alcohol potentiation and anticonvulsant and skeletal muscle relaxant effects, even seen with midazolam mechanism of action. ![]() This is turn produce hyperpolarization of the postsynaptic cell membrane, while rendering postsynaptic neurons more resistant to excitation, and midazolam mechanism of action. Benzodiazepines do not activate the GABAA receptors but rather enhance the affinity of the receptors for GABA, as a result of which, there is enhanced opening of chloride gating channels resulting in increased chloride conductance. ![]()
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